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Methods and systems
With pharmacology as the major target area, Pipeline Biotech
performs both in vivo and in vitro studies, although in vivo studies
are used more frequently. In vivo studies (animal studies) are used
to define disease models and interpret the results of assays in
these models, whereas in vitro test systems (cell-based research)
are used to screen drug candidate action and enable mechanistic
studies during the different stages of disease progress.
Naturally, the method used depends on the
specific aims of the assignment in question.
 Mice
and rats
Mice and rats are the disease models used most frequently. We only
use well-established and scientifically recognised models so as to
be sure that the effects of the agents tested can be validated both
predicatively and indicatively. Alternatively, new models can be
defined and validated prior to the research – and always in close
co-operation with the client.
In
cases where mice and rats are not considered the most suitable of
models, smaller non-GLP studies can be performed using dogs and/or
pigs.
Client models
The
reliability of the research results depends on the suitability of
the models used. If our models are not appropriate to your
particular activities, we can establish and validate your own models
– or develop new ones to meet your specific requirements. We can
provide you with all the assistance you need in developing new
experimental models based on pharmacological, surgical or genetic
techniques so as to reproduce human pathological syndromes.
Target areas
So
far, studies carried out by Pipeline Biotech have been related to
diseases such as cancer, diabetes, asthma, allergy, inflammation,
osteoporosis and hormonal dysfunction. However, we also routinely
carry out research studies aimed at the areas of bioavailability,
biodistribution and metabolism. Recently, activities related to
functional genomics have become increasingly relevant. In vivo
screenings help us discover how genes work, how and when they are
expressed, how they interact, and what roles they play in health and
in the development of disease. Functional genomics is the area of
research most likely to provide useful new knowledge for the medical
industry as it is set to identify thousands of new biological
targets for drug development.
Experience makes experts. Open-minded experts make discoveries.
We
at Pipeline Biotech are always ready to tread new paths and apply
new approaches. |
